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Topical Clindamycin vs. Topical Clindamycin Phosphate

Feature Clindamycin (free base) Clindamycin Phosphate (prodrug)

Active form Already active; no conversion needed Hydrolyzed by
skin enzymes to free clindamycin

Use Skin infections, acne, and other bacterial conditions Acne vulgaris,
mild‑to‑moderate skin irritation is less common

Release profile Rapid; drug available immediately S