CD4+ T cells are important to prevent disseminated TB, and on the identical time, Mtb employs a selection of mechanisms to undermine efficient macrophage-CD4+ T cell
interactions8,15. In well-formed granulomas of non-human primates,
CD4+ T cells are restricted to the lymphocytic cuff,
away from the central core of infected macrophages16.Mtb additionally impairs the power of infected macrophages to
present antigen to T cells18,19,20,21,22,23,24. Thus, approaches to i |
